The Museum David and Alice van Buuren is a private house built from 1924 to 1928 for banker and art collector David van Buuren and his wife Alice in Brussels, Belgium. The house was decorated by David and Alice as a total work of art to present their art collection in a rich Art Deco interior. The house is surrounded by gardens designed by Jules Buyssens in 1925 and René Pechère in 1968 and 1970. The house was declared a National Heritage site in 2001. The private house became a museum in 1975 according to the testament of Alice van Buuren.

David van Buuren (1886-1955) was born into a Jewish family in Gouda, Netherlands. He settled in Brussels in 1909 to become an important private banker. He married the Belgian Alice Piette (1890-1973) in 1922. David van Buuren asked his nephew and architect Johan Franco to start working on the plan of his future house in Brussels. From 1924-1928 the van Buurens commissioned the Belgian architects Léon Govaerts and Alexis Van Vaerenbergh to built their house on the Léo Errera Avenue in Uccle following Franco's sketches. The outdoor architecture is typical of the Amsterdam School, while its Art Deco interior was decorated by Belgian, French and Dutch designers with rare furniture, carpets and stained-glass windows.

From 1928 to 1970 the van Buurens hosted people such as Raoul Dufy, Jacques Prévert, René Lalique, Sergei Diaghilev, Erik Satie, René Magritte, David Ben-Gurion. The private house became a museum in 1975 according to the testament of Alice van Buuren.

David van Buuren decorated his house with paintings from James Ensor, Joachim Patinir, Pieter Bruegel the Elder, Hercules Seghers, Pieter Jansz Saenredam, Tsuguharu Foujita, Kees van Dongen, Vincent van Gogh, Henri Fantin-Latour, Rik Wouters, Gustave De Smet, Xavier Mellery en Constant Permeke. David was the patron of Belgian expressionist painter Gustave van de Woestijne. Van Buurens collections consists of 32 paintings of Van de Woestijne.

The living room is decorated with a rich collection of modernist carpets designed by the Dutch designer Jaap Gidding and a grand piano made of rosewood designed by Julius Blüthner. Jan Eisenloeffel designed the 500 kg (1,100 lb) Art Deco chandelier in the entrance hall.

On 16 July 2013, the paintings "Shrimps and Shells" of Belgian painter James Ensor and "The Thinker" by Dutch artist Kees van Dongen and eight small works by old masters were stolen.

The 1.2 ha (3.0-acre) garden is divided in three parts: the "Picturesque Garden" designed by Jules Buyssens in 1925, the "Labyrinth", inspired by the Song of Songs and decorated with seven sculptures by the Belgian sculptor André Willequet and the "Garden of the Hearts" designed by Belgian landscape designer René Pechère in 1968 and 1970 respectively.